The present study investigates the effects of chemical reaction and radiation effects on pulsatile hydromagnetic flow of an Oldroyd-B fluid in a porous medium with slip and convective boundary conditions. Analytical expressions for velocity, temperature, concentration, Nusselt number, and Sherwood number distributions are obtained. The effects of different parameters on the dimensionless velocity, temperature, and concentration have been discussed numerically and explained graphically. Analysis indicates that the temperature distribution decreases for a given increase in heat transfer Biot number and Prandtl number, while it increases with an increase in Hartmann number. Further, the concentration distribution decreases with an increase in the Soret number and the heat transfer Biot number, while it decreases for a given increase in the chemical reaction parameter. © 2017 by Begell House, Inc.