The main aim of this study is to present the effects of Soret & Dufour on MHD mixed convection flow of a viscous fluid towards a vertical plate embedded in a porous medium in the existence of slip, radiation and chemical reaction. The numerical solutions are acquired using shooting method, and the governing equations are reformed into ordinary differential equations by similarity transformation. The present results compared with previously presented works are found in good agreement on several distinct cases. The effects of different parameters on velocity, temperature, and concentration distributions are illustrated graphically. The variation of diverse parameters on local skin friction, rates of heat, and mass transfer is obtainable in tabular arrangement. The velocity and temperature increase on increasing the Dufour parameter, and the concentration profiles decrease when chemical reaction parameter increases. © 2017 Sharif University of Technology.