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Chiral modulation of amyloid beta fibrillation and cytotoxicity by enantiomeric carbon dots
R. Malishev, E. Arad, , S. Shaham-Niv, S. Kolusheva, E. Gazit, R. Jelinek
Published in Royal Society of Chemistry
PMID: 29947369
Volume: 54
Issue: 56
Pages: 7762 - 7765
Enantiomeric carbon dots (C-dots) synthesized from l-lysine or d-lysine, modulate aggregation and cytotoxicity of amyloid beta-42 (Aβ42), the primary constituent of the amyloid plaques associated with Alzheimer's disease. In particular, l-Lys-C-dots dramatically remodeled Aβ42 secondary structure and fibril morphologies, as well as inhibited Aβ42 cytotoxicity and membrane interactions. © The Royal Society of Chemistry.
About the journal
JournalData powered by TypesetChemical Communications
PublisherData powered by TypesetRoyal Society of Chemistry