Header menu link for other important links
X
Chiral modulation of amyloid beta fibrillation and cytotoxicity by enantiomeric carbon dots
R. Malishev, E. Arad, , S. Shaham-Niv, S. Kolusheva, E. Gazit, R. Jelinek
Published in Royal Society of Chemistry
2018
PMID: 29947369
Volume: 54
   
Issue: 56
Pages: 7762 - 7765
Abstract
Enantiomeric carbon dots (C-dots) synthesized from l-lysine or d-lysine, modulate aggregation and cytotoxicity of amyloid beta-42 (Aβ42), the primary constituent of the amyloid plaques associated with Alzheimer's disease. In particular, l-Lys-C-dots dramatically remodeled Aβ42 secondary structure and fibril morphologies, as well as inhibited Aβ42 cytotoxicity and membrane interactions. © The Royal Society of Chemistry.
About the journal
JournalData powered by TypesetChemical Communications
PublisherData powered by TypesetRoyal Society of Chemistry
ISSN13597345