This paper propose the closed loop control of multilevel inverter. Multilevel inverter (MLI) used is five-level neutral point clamped inverter. The switches of inverter are controlled by multicarrier phase opposition disposition SPWM technique. This type of multilevel configuration is deployed to reduce total harmonics distortion compared to two-level conventional PWM inverter. Fuzzy logic controller is designed for closed loop control of RMS voltage of multilevel inverter. The performance of fuzzy logic-based closed loop control of multilevel inverter is studied using Simulink tool of MATLAB. © 2020, Springer Nature Singapore Pte Ltd.