Synthetically easy, a new chemodosimeter-type chromogenic and fluorogenic chemosensor L was developed by condensing 1-aminopyrene with the vitamin B6 cofactor pyridoxal for the selective detection of Fe3+. Receptor L exhibits a rapid colorimetric response from yellow to colourless and a distinct fluorescence enhancement at 441 nm with Fe3+ due to the cleavage of imine linkage. The optical responses from L in the presence of Fe3+ ions are highly specific, interference-free, can be monitored by smartphone and also observed within the live HeLa cells. © 2018 Elsevier B.V.

Priyankar Paira

Department of Chemistry

School of Advanced Sciences

Vellore Campus

Kumar R

Computer Science

School of Computer Science and Engineering

Chennai Campus

Upadhyay Y

Anand T

Babu L.T

Kumar SK A

Sahoo S.K.

Vellore Institute of Technology (VIT) is a private university located in&nbsp;Tamil Nadu, India. Founded in 1984, as Vellore Engineering College, the institution offers 20 undergraduate, 34 postgraduate, four integrated and four research programs. It has campuses in Vellore, Amravati, Bhopal and Chennai.

VIT is one of the top ranked private universities in India according to NIRF, THE and QS Rankings.&nbsp;Govt. of India has recognized&nbsp;VIT, Vellore as an&nbsp;Institution of Eminence. This has allowed VIT to take independent quality initiatives and move up in world ranking.

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VIT University

Journal of Photochemistry and Photobiology A: Chemistry

This communication focusses on the synthesis of red fluorescent lysozyme cocooned gold nanoclusters (Lyso-AuNCs) that have been successfully applied for the selective and specific recognition of the vitamin B6 cofactor pyridoxal-5'-phosphate (PLP). The red fluorescence of Lyso-AuNCs showed remarkable color change to yellow upon conjugation with PLP due to the formation of a Schiff base between the free -NH2 present in the lysozyme and the -CHO group of PLP. The developed PLP conjugated Lyso-AuNCs (PLP_Lyso-AuNCs) was applied for the selective turn-on recognition of Zn2+ ions in aqueous medium. The yellow fluorescence of PLP_Lyso-AuNCs exhibited significant enhancement at 475 nm in the presence of Zn2+ producing bluish-green fluorescence attributed to the complexation-induced aggregation of nanoclusters. The nanoprobe exhibits nanomolar limit of detection for Zn2+ ions (39.2 nM) and the practicality of the nanoprobe was validated in various environmental water samples and biological plasma, urine, and beetroot extract, with fairly good recovery percent. Also, the system was successfully implemented for the intracellular detection and monitoring of Zn2+ in live HeLa cells. Graphical abstract Applications of red emitting lysozyme cocooned gold nanoclusters (Lyso-AuNCs) for the selective recognition of the vitamin B6 cofactor pyridoxal-5'-phosphate (PLP) and the conjugated nano-assembly PLP_Lyso-AuNCs for turn-on detection of Zn2+ ions in various environmental and biological samples.

Analytical and Bioanalytical Chemistry

A biomimetic approach to conjugate vitamin B6 cofactor with the lysozyme cocooned fluorescent AuNCs and its application in turn-on sensing of zinc(II) in environmental and biological samples

A novel fluorescent receptor L was developed for the selective detection of important bioactive analytes.

Dalton Transactions

Three-in-one type fluorescent sensor based on a pyrene pyridoxal cascade for the selective detection of Zn(ii), hydrogen phosphate and cysteine

One-pot approach was adopted for the synthesis of highly luminescent near-infrared (NIR)-emitting gold nanoclusters (AuNCs) using bovine serum albumin (BSA) as a protecting agent. The vitamin B6 cofactor pyridoxal was conjugated with the luminescent BSA-AuNCs through the free amines of BSA and then employed for the nanomolar detection of Hg2+ in aqueous medium via selective fluorescence quenching of AuNCs. This nano-assembly was successfully applied for the real sample analysis of Hg2+ in fish, tap water and river water. The study also presents chemically-modified cellulosic paper strips with the pyridoxal conjugated BSA-AuNCs for detecting Hg2+ ion up to 1 nM. © 2016 Elsevier B.V.

Biosensors and Bioelectronics

Chemically modified cellulose strips with pyridoxal conjugated red fluorescent gold nanoclusters for nanomolar detection of mercuric ions

ChemistrySelect

Vitamin B6 Cofactor Derivative: A Dual Fluorescent Turn-On Sensor to Detect Zn2+ and CN− Ions and Its Application in Live Cell Imaging

Dual lanthanide-doped complexes: the development of a time-resolved ratiometric fluorescent probe for anthrax biomarker and a paper-based visual sensor

Combined use of spectrophotometer and smartphone for the optical detection of Fe 3+ using a vitamin B 6 cofactor conjugated pyrene derivative and its application in live cells imaging

Journal	Data powered by TypesetJournal of Photochemistry and Photobiology A: Chemistry
Publisher	Data powered by TypesetElsevier BV
ISSN	1010-6030
Open Access	0