Suthindhiran K

Department of Bio-Medical Sciences

School of Bio Sciences and Technology

Vellore Campus

Raguraman V

Vellore Institute of Technology (VIT) is a private university located in&nbsp;Tamil Nadu, India. Founded in 1984, as Vellore Engineering College, the institution offers 20 undergraduate, 34 postgraduate, four integrated and four research programs. It has campuses in Vellore, Amravati, Bhopal and Chennai.

VIT is one of the top ranked private universities in India according to NIRF, THE and QS Rankings.&nbsp;Govt. of India has recognized&nbsp;VIT, Vellore as an&nbsp;Institution of Eminence. This has allowed VIT to take independent quality initiatives and move up in world ranking.

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VIT University

Journal of Cluster Science

Magnetosomes are nanosized iron oxide particles surrounded by lipid membrane synthesized by magnetotactic bacteria (MTB). Magnetosomes have been exploited for a broad range of biomedical and biotechnological applications. Due to their enormous potential in the biomedical field, its safety assessment is necessary. Detailed research on the toxicity of the magnetosomes was not studied so far. This study focuses on the toxicity assessment of magnetosomes in various models such as Human RBC’s, WBC’s, mouse macrophage cell line (J774), Onion root tip and fish (Oreochromis mossambicus). The toxicity in RBC models revealed that the RBC’s are unaltered up to a concentration of 150&nbsp;µg/ml, and its morphology was not affected. The genotoxicity studies on WBC’s showed that there were no detectable chromosomal aberrations up to a concentration of 100&nbsp;µg/ml. Similarly, there were no detectable morphological changes observed on the magnetosome-treated J774 cells, and the viability of the cells was above 90% at all the tested concentrations. Furthermore, the magnetosomes are not toxic to the fish (O. mossambicus), as no mortality or behavioural changes were observed in the magnetosome-treated groups. Histopathological analysis of the same reveals no damage in the muscle and gill sections. Overall, the results suggest that the magnetosomes are safe at lower concentration and does not pose any potential risk to the ecosystem.

Fulltext

3 Biotech

Toxicity assessment of magnetosomes in different models

Medical Oncology

Crizotinib-loaded polymeric nanoparticles in lung cancer chemotherapy

South Asian Journal of Cancer

Crizotinib: A comprehensive review

Microbiological Research

Magnetotactic bacteria, magnetosomes and their application

International Journal of Pharmaceutics

Preparation of chains of magnetosomes, isolated from Magnetospirillum magneticum strain AMB-1 magnetotactic bacteria, yielding efficient treatment of tumors using magnetic hyperthermia

Comparative Studies on Functionalization of Bacterial Magnetic Nanoparticles for Drug Delivery

Journal	Data powered by TypesetJournal of Cluster Science
Publisher	Data powered by TypesetSpringer Science and Business Media LLC
ISSN	1040-7278
Open Access	0