The rapid development of urban populations and ensuring a limitation of area have impressively altered the residential development of the city. This study mainly focuses on modern high-rise buildings and their structural design mainly governed by lateral loads and this lateral load resisting is provided by either interior or exterior structural systems. The interior system comprises shear wall core, braced frame whereas the loads are resisted by a centrally loaded system. The exterior system comprises of a framed tube, braced tube and diagrid whereas the loads are resisted by elements provided at periphery. It is noted that the selected structural system is to be well utilized in structural efficiency and also in satisfying the design requirements. In our study, the effect of the diagrid system on seismic behavior of high rise building of 18 stories steel building of aspect ratio 4.5 has been considered. The time history analysis was performed by SAP2000. The response of the diagrid structure has been compared with braced tube structure. It has been absorbed that diagrid structure provides more lateral resistant against seismic forces compared with braced tube structure. © 2020, World Research Association. All rights reserved.