Comparative toxic effect of nitrogen mustards (HN-1, HN-2, and HN-3) and sulfur mustard on hematological and biochemical variables and their protection by DRDE-07 and its analogues

M. Sharma; Vijayaraghavan R; O.P. Agrawal

doi:10.1177/1091581810365730

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Comparative toxic effect of nitrogen mustards (HN-1, HN-2, and HN-3) and sulfur mustard on hematological and biochemical variables and their protection by DRDE-07 and its analogues

M. Sharma, , O.P. Agrawal

Published in SAGE Publications Inc.

2010

DOI: 10.1177/1091581810365730

PMID: 20466873

Volume: 29

Issue: 4

Pages: 391 - 401

Abstract

The chemical warfare agents sulfur mustard (SM) and nitrogen mustards (HN-1, HN-2, and HN-3) are highly reactive vesicants. The study was planned to investigate the protective efficacy of amifostine, DRDE-07 and their analogues, and few conventional antidotes (30 minutes pretreatment) against dermally applied SM and nitrogen mustards in preventing hematological and biochemical changes in mice. Mustard agents (1.0 median lethal dose [LD50]) induced a significant decrease in the body weight and spleen weight. © The Author(s) 2010.

Topics: Nitrogen mustard (62)% and Sulfur mustard (58)%

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