Medicinal plants are considered to be a prosperous source of ingredients which can be used in drug improvement and production. In addition to these, plants play an essential role in the improvement of human culture around the world. The family Cucurbitaceae are usually called as gourds that grow widely in tropical, subtropical, arid deserts and temperate locations. Several bioactive containing plants are present in this family so it is used widely from ancient time for their medicinal values. The study aimed to investigate qualitative and quantitative phytochemical screening, antimicrobial and antioxidant activity of methanol and petroleum ether leaf extract of Momordica charantia, Citrullus lanatus, Coccinia grandis and Lageneria siceraria. © RJPT All right reserved.