As the world is marching into the era of the Internet of things (IoTs) and artificial intelligence (AI), the most vital requirement for reliable hardware development is an ultrafast response time and no performance degradation. As a reliable indicator of human physiological health, blood pressure measurement is vital in humans' daily lives, which creates a huge demand in monitoring and diagnosing blood pressure problems. The triboelectric nanogenerator (TENG) is one of the best energy devices and healthcare applications in the new era since triboelectrification is a universal and ubiquitous effect with an abundant choice of materials. TENG is reliable in physiological monitoring applications and has many benefits, including being inexpensive, easy to manufacture, and lightweight, having self-powered properties, and being available in a wide range of materials. In this review, triboelectric nanogenerator based wrist pulse measurement was summarized for blood pressure monitoring and diagnosis applications. As per the Ayurveda, imbalance in three essential components of the wrist pulse implies the human health status and reveals symptoms for diseases. The design of different TENG-based blood pressure sensors, sensing mechanisms, performance, merits, and demerits of each method are discussed. © 2020 American Chemical Society. All rights reserved.