This article discusses a detailed Computational Fluid Dynamics study to assess the efficiency of the conformal heat and cool system associated with an injection molding process. The study involves characterizing the fluid flow and heat transfer behavior in an injection mold designed with conformal heat and cool circuits. The key result of interest is uniform temperature distribution over the cavity profile. Further, the study involves identifying the important geometrical as well as flow parameters that have the significant influence on optimizing the heat up and cool down time, which promotes uniform temperature distribution on the cavity profile. The formation of uniform temperature distribution leads to the better quality and aesthetics of the injection molded parts. Importantly, molding defects such as knit lines, flow marks, etc., are reduced to a greater extent compared to conventional injection molding processes. Copyright © (2014) by the Society of Plastics Engineers All rights reserved.