In the present study, in silico analysis was employed to identify the action of marine bioactive compounds against KSHV targets. Virulence factor analysis of KSHV from literature review,identified three proteins LANA1, vIRF3/LANA2 and PF-8 as a putative targets. By virtual screening four potential bioactive compounds Ascorbic acid, Salicylihalamide A, Salicylihalamide B and Frigocyclinone were predicted to possess desirable drug-like properties. Hence, determined as the good lead molecule against Molecular dynamics simulation reveals that LANA-1frigocyclinone complex shows better stability and conformation. Therefore frigocyclinone can act s a potential compound and further experiments are required to optimize the activity of the compound. © 2019 Oriental Scientific Publishing Company. All rights reserved.