Several polymetallic anionic clusters display a strong tendency to form robust ion-pairs with appropriate counter cations. We have isolated decavanadate cluster [H 2 V 10 O 28 ] 4– with, hitherto unreported, dimethylammonium ions, [N(CH 3 ) 2 H 2 ] 4+ as counter cations from vanadyl sulfate and N,N’-dimethylformamide (DMF). It is proposed, for the first time, that dimethylammonium ions are formed by reduction and simultaneous decarboxylation of DMF with oxidation of vanadyl sulfate occurring concomitantly under specified reaction conditions. The different colors observed during the course of the reaction are monitored by UV-Visible spectrophotometry. The structure of isolated cluster compound with four counter cations is confirmed by single crystal X-ray diffraction techniques. The compound is also tested for its DNA/BSA binding efficacy and cytotoxicity on human epitheloid cervix carcinoma (HeLa) cells along with vanadates—vanadium pentoxide and ammonium metavanadate. Based on the results, the cluster shows better IC 50 and binding values than vanadates. (Figure presented.). © 2018, © 2018 Informa UK Limited, trading as Taylor &amp; Francis Group.

Sheela A

Department of Chemistry

School of Advanced Sciences

Vellore Campus

Chinnapullaih C

Vellore Institute of Technology (VIT) is a private university located in&nbsp;Tamil Nadu, India. Founded in 1984, as Vellore Engineering College, the institution offers 20 undergraduate, 34 postgraduate, four integrated and four research programs. It has campuses in Vellore, Amravati, Bhopal and Chennai.

VIT is one of the top ranked private universities in India according to NIRF, THE and QS Rankings.&nbsp;Govt. of India has recognized&nbsp;VIT, Vellore as an&nbsp;Institution of Eminence. This has allowed VIT to take independent quality initiatives and move up in world ranking.

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Concomitant reduction of dimethylformamide and oxidation of vanadyl sulfate to N,N′-dimethylammonium decavanadate cluster and DNA, BSA binding, and cytotoxicity (HeLa) studies

Journal of Coordination Chemistry

The physicochemical properties, thereby the biological efficacy, of metal complexes are affected based on their structure and geometry that vary in the presence of coordinating and non-coordinating solvents. To investigate this, in the present work, we synthesized three hitherto unreported β-diketone-based oxovanadium(IV) complexes, namely [VO(tfdmh)2] (tfdmh =1,1,1-trifluro-5,5-dimethyl-2,4-hexanedione), [VO(dmh)2] (dmh = 2,2-dimethyl-3,5-hexanedione) and [VO(dbm)2] (dbm = 1,3-diphenylpropane-1,3-dione), and characterized them using electron paramagnetic resonance, UV–visible, Fourier transform infrared and electrospray ionization mass spectroscopies and single-crystal X-ray diffraction. The structural changes in the presence of dichloromethane, dimethylsulfoxide and dimethylformamide were analysed using spectroscopic techniques. Further, in vitro glucose uptake efficacy and cytotoxicity were assessed using C2C12 (rat skeletal muscle) and HeLa (human cervical cancer) cell lines, respectively. Copyright © 2017 John Wiley &amp; Sons, Ltd.

Applied Organometallic Chemistry

Effect of solvent coordination on the structure of β-diketone-based vanadyl complexes and assessment of in vitro antidiabetic activity and cytotoxicity

Novel tridentate ONO hydrazone ligand (HL) and the corresponding vanadium(V) complex, [VO(HL)(Benz)], based on the ligand and benzhydroxamic acid, were synthesized and characterized using UV–visible, Fourier transform infrared, NMR and mass spectral studies. In order to assess the binding efficacy of the synthesized complex with DNA, UV absorption spectral titrations, fluorescence displacement assays using ethidium bromide and acridine orange dyes, circular dichroism, viscosity and molecular docking studies were carried out. Based on the results obtained, it is evident that the complex shows significant intercalating ability almost comparable to that of the standard intercalator drug cisplatin. The binding affinity values for the [VO(HL)(Benz)] complex and cisplatin were found to be (3.84 ± 0.08) × 104 M−1 and (4.27 ± 0.012) × 104 M−1. In addition, the cytotoxicity of [VO(HL)(Benz)] was also assessed by MTT assay against the MCF-7 cell line. Copyright © 2016 John Wiley &amp; Sons, Ltd.

DNA binding behaviour of mixed ligand vanadium(V) complex based on novel tridentate hydrazone and benzhydroxamic acid ligand systems

Two diketone based oxovanadium complexes, viz., bis(4,4,4-trifluoro-1-phenylbutane-1,3-dionato)oxovanadium(IV) (1) and bis(1,1,1-trifluoropentane-2,4-dionato)oxovanadium(IV) (2), have been synthesized and characterized by spectroscopic and analytical techniques. The DNA binding and the cleaving ability of the complexes is assessed by UV-vis spectroscopy, fluorescence spectroscopy, viscometry and gel electrophoretic studies. The DNA binding constant values (Kb) are found to be 1.95±0.16×103M-1 for complex 1 and 1.064±0.17×103M-1 for complex 2, respectively. Based on the results of the spectral and viscosity studies, it is observed that the complexes, interestingly, have preferred minor groove binding with DNA. Further, the concentration-dependent oxidative cleavage pattern of pBR322 in the presence of the activating reagent, hydrogen peroxide, has also been discussed. In addition, the complexes have shown moderate cytotoxic activity by inducing apoptosis against the cervical cancer cell line, HeLa. The results of in silico analysis and logP predictions are found to be in good agreement with the experimental observations. Thus, synthesized oxovanadium complexes have displayed promising DNA binding behavior and DNA cleavage activity with moderately cytotoxic nature. © 2015 Elsevier B.V.

Journal	Journal of Coordination Chemistry
Publisher	Informa UK Limited
ISSN	0095-8972
Open Access	0