Management of anesthesia is significant for both surgery and intensive care. The intravenous anesthetics are widely used to provide steady maintenance and speed recovery compared with inhaled anesthetics. The current work analyses the technique to describe the effects of anesthetic drug Propofol in the introduction of hypnosis on a patient during surgery procedure. The model is developed by considering the regular three-compartmental pharmacokinetics/pharmacodynamics Wiener model and conventional controller for adjustment of Depth of hypnosis through Bispectral Index scale (BIS) value. It provides a reliable and safe methodology for infusing anesthesia using closed loop control technology and analysis of human electroencephalogram (EEG) to measure the depth of anesthesia in patients. Two patient sets of datasets are considered during this procedure. The outcomes obtained for different patients show that the standard model fits the data with the developed Simulink based model. The paper designs the plasma concentration 3-compartmental model using PID controller to control the depth of hypnosis and infusion rate during surgery through the reference value BIS of patient. Because of simplicity and robustness of PID controller, it is widely used for industrial plants. The developed model is compared with sliding mode controller. The results shows the transient control system characteristics of delay time, rise time, peak time, maximum overshoot and settling time. © BEIESP.