The main objective of this work is to investigate the factors influencing the NOx control of a stationary diesel engine fuelled with crude rice bran oil blend with lesser effect on smoke density and brake thermal efficiency (BTE). Fuel injection timing, percentage of EGR, and fuel injection pressure are chosen as the factors for the objective and NOx emission, smoke density, and BTE are considered as the response variables. To critically analyze the effects of the chosen factors on the objective three levels were chosen in each factor and the experiments were designed by following the design of experiments method. Taguchi's L9 orthogonal array was used to conduct the tests with different combination of factor levels. Through analysis of variance (ANOVA) method, the most influencing factors and also the significance of each factor affecting each response variable were found out. Response graph was drawn for each response variable to determine the optimum combination of factor levels in achieving the objective and the obtained combination was confirmed experimentally. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.