A series of imidazolium based Dicationic Ionic Liquids (ILs) have been prepared and characterized successfully. Derivatives are prepared keeping the alkyl chain of alkylimidazole as methyl, ethyl, and propyl groups and the linker dibromoalkane is varied as an ethyl, propyl and butyl group. The variations of anions like Br−, BF4 − and PF6 − impact their morphological appearance like amorphous powder to low melting white solids or a hygroscopic nature. Refluxing the alkylimidazoles and dibromoalkanes in toluene for 24 h and an easy workup procedure makes this methodology more time saving for detailed exploration of Dicationic ILs. The formation of dicationic ILs with their anions like Br−, BF4 −, PF6 − has been confirmed with 1H, 13C, 31P and 19F NMR spectroscopy as well as the High Resolution Mass Spectroscopy Electron Impact technique. © 2016, Springer Science+Business Media Dordrecht.

Pundlik Rambhau Bhagat

Department of Chemistry

School of Advanced Sciences

Vellore Campus

Aher S.B

Vellore Institute of Technology (VIT) is a private university located in&nbsp;Tamil Nadu, India. Founded in 1984, as Vellore Engineering College, the institution offers 20 undergraduate, 34 postgraduate, four integrated and four research programs. It has campuses in Vellore, Amravati, Bhopal and Chennai.

VIT is one of the top ranked private universities in India according to NIRF, THE and QS Rankings.&nbsp;Govt. of India has recognized&nbsp;VIT, Vellore as an&nbsp;Institution of Eminence. This has allowed VIT to take independent quality initiatives and move up in world ranking.

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VIT University

Research on Chemical Intermediates

Ag (I)-N-heterocyclic carbene (Ag–NHC) complexes (S1–S6) were synthesized from di-cationic ionic liquids (DCILs-1–6) and characterized by NMR, FT-IR, and EI-MS studies, and evaluated for cytotoxicity against human colorectal carcinoma cell line (HCT-116) using methylthiazolyldiphenyl-tetrazolium bromide assay. The DCILs displayed good patterns of cytotoxicity which was improved greatly upon metallation and were found to be in a direct correlation with the increase in the alkyl chain that correlates with lipophilicity. Amongst the Ag–NHCs studied, S1, S5, and S6 have shown 85.95, 99.01 and 99.70% growth inhibition at the concentrations of 120, 120 and 60 µM, respectively. In order to depict the putative mechanism adopted by S6, HCT-116 cells were treated with S6 and stained using acridine orange/ethidium bromide (AO/EtBr), and the results displayed a significant induction of apoptosis in HCT-116 cells as evident from the green-orange fluorescence. Furthermore, DAPI staining confirmed that the S6-treated HCT-116 cells underwent chromatin condensation and DNA fragmentation. Since mitochondria play a prominent role in apoptosis, we further examined the mitochondrial membrane potential (MMP) and reactive oxygen species (ROS) formation. Interestingly, the S6-treated HCT-116 cells demonstrated a higher ROS and depolarization of MMP, which suggests that S6 can induce mitochondria-mediated intrinsic apoptosis in cancer cells. Besides these consequences, HCT-116 cells also exhibited a lower level of oxidant defensive protein catalase. Taken altogether, the current study suggests that Ag–NHCs can reduce anti-oxidative protein catalase following an increase in ROS level, thereby triggering apoptosis in cancer cells. © 2017, Springer Science+Business Media Dordrecht.

Cytotoxic behavior of binuclear silver N-heterocyclic carbenes in HCT 116 cells and influence of substitution on cytotoxicity

Herein, we report the synthesis of a new series of amide functionalized dicationic benzimidazolium based ionic liquids (DBimILs) and appraised their efficacy towards perceptive esterification of carboxylic acids with alkyl/allyl/aryl halides in presence of triethylamine. The amide groups present in this new series of DBimILs are expected to form hydrogen bonding with the carboxylic acids and this could facilitate the esterification reactions under mild conditions devoid of any added catalyst or organic solvent. The plausible mechanism for the enhanced catalytic activity in presence of this new series of ILs has been proposed. The corresponding alkyl/allyl/aryl esters isolated from this reaction were of high purity after simple extraction, which wipe out the necessity for further purification. This protocol addresses clean methodology and the efficient recyclability as well as reusability of the catalyst. © 2014 Elsevier B.V.

Applied Catalysis A: General

Facile esterification of carboxylic acid using amide functionalized benzimidazolium dicationic ionic liquids

Separation Science and Technology

Separation of Aromatic Solvents from the Reformate Fraction of an Oil Refining Process using Extraction by a Designed Ionic Liquid

Journal of Chemical Sciences

Engineering reactors for catalytic reactions

Electrochimica Acta

A novel organic ionic plastic crystal electrolyte for solid-state dye-sensitized solar cells

Scientific Reports

Highly Efficient Plastic Crystal Ionic Conductors for Solid-state Dye-sensitized Solar Cells

Convenient synthesis of imidazolium based dicationic ionic liquids

Journal	Data powered by TypesetResearch on Chemical Intermediates
Publisher	Data powered by TypesetSpringer Science and Business Media LLC
ISSN	0922-6168
Open Access	No