Herein we report a copper catalyzed tandem reaction for the therapeutically important pyrrolo-/pyrido[2,1-b] benzo[d ][1,3]oxazin-1-ones using 2-aminobezyl alcohols, green solvent medium, alkynoic acids, under ligand and base free conditions.

Rajasekhara Reddy Sabbasani

Department of Chemistry

School of Advanced Sciences

Vellore Campus

Naidu S

Vellore Institute of Technology (VIT) is a private university located in&nbsp;Tamil Nadu, India. Founded in 1984, as Vellore Engineering College, the institution offers 20 undergraduate, 34 postgraduate, four integrated and four research programs. It has campuses in Vellore, Amravati, Bhopal and Chennai.

VIT is one of the top ranked private universities in India according to NIRF, THE and QS Rankings.&nbsp;Govt. of India has recognized&nbsp;VIT, Vellore as an&nbsp;Institution of Eminence. This has allowed VIT to take independent quality initiatives and move up in world ranking.

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VIT University

RSC Advances

A symmetrical azo-based Luminol derivative 2 was synthesized using catalytic dehydrogenative coupling reaction procedure. This symmetrical molecule shows blue fluorescence in polar aprotic solvents (λmax = 450 nm). With an increase in aqueous content 2 was exhibiting aggregation caused fluorescence quenching (ACQ) with a red shift of 30 nm (λmax = 480 nm). Distinct emission features were observed for this molecule&nbsp; with a variation in the pH range. In basic medium, deprotonated form of 2 shows fluorescence quenching followed by enhancement of&nbsp; green chemiluminescence (λmax = 490 nm) with H2O2/Fe3+catalytic system. The fluorescence and chemiluminescent (CL) properties of 2 were compared with its parent luminol 1, The &nbsp;CL emission intensity of 2 was found to be about 16 times higher than that of 1. In addition, HOMO-LUMO energy gap for 2 was also calculated using density functional theory (DFT) studies.

Fulltext

Oriental Journal of Chemistry

Green Chemiluminescence of Highly Fluorescent Symmetrical Azo-Based Luminol Derivative

Copper-catalyzed tandem reaction in ionic liquid: an efficient reusable catalyst and solvent media for the synthesis of fused poly hetero cyclic compounds

ChemistrySelect

A Green and Recyclable Copper and Ionic Liquid Catalytic System for the Construction of Poly-heterocyclic CompoundsviaOne-pot Tandem Coupling Reaction

Herein we report the synthesis of new hydrophobic <a href="https://www.sciencedirect.com/topics/chemistry/ionic-liquid">ionic liquid</a> by simple manipulations starting from d-galactose. The synthesized ionic liquid 1-methyl-3-(((3aS,5S,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-5-yl)methyl)-1H-imidazol-3-ium hexafluorophosphate(V) (IL 5) was completely characterized by sophisticated analytical techniques. IL 5 was investigated as adsorbent for the sequestration of Pb2&nbsp;+ ions from <a href="https://www.sciencedirect.com/topics/physics-and-astronomy/aqueous-solutions">aqueous solution</a> and this is proved as its potential application. Batch mode studies were done, by varying the batch parameters such as pH, IL dose, contact time, initial <a href="https://www.sciencedirect.com/topics/chemistry/metal-ion">metal ion</a> concentration and temperature. Various mathematical models such as kinetic models and isotherms were employed to understand the mechanism of sequestration. Thermodynamic investigations suggest that the sequestration of Pb2&nbsp;+ ions is spontaneous and exothermic in nature. The maximum loading capacity of IL 5 was found to be 374.9&nbsp;mg&nbsp;g−&nbsp;1. Desorption and regeneration analysis revealed the repeated use of IL 5 in industrial processes. These results suggest that IL 5 is a potential <a href="https://www.sciencedirect.com/topics/chemistry/sorbent">sorbent</a> for the elimination of Pb2&nbsp;+ ions from aqueous solution.

Journal of Molecular Liquids

Hydrophobic d-galactose based ionic liquid for the sequestration of Pb2+ ions from aqueous solution

Catalytic oxidation reactions often suffer from drawbacks such as low yields and poor selectivity. Particularly, selective oxidation of alcohols becomes more difficult when a compound contains more than one oxidizable functional group. In order to deliver a methodology that addresses these issues, herein we report an efficient, aerobic, chemoselective and simplified approach to oxidize a broad range of benzyl and propargyl alcohols containing diverse functional groups to their corresponding aldehydes and ketones in excellent yields under mild reaction conditions. Optimal yields were obtained at room temperature using 1 mmol substrate, 10 mol % copper(I) iodide, 10 mol % 4-dimethylaminopyridine (DMAP), and 1 mol % 2,2,6,6-tetramethylpiperidine 1-oxyl (TEMPO) in acetonitrile, under an oxygen balloon. The catalytic system can be applied even when sensitive and oxidizable groups such as alkynes, amines, and phenols are present; starting materials and products containing such groups were found to be stable under the developed conditions.

ChemistryOpen

Chemoselective Oxidation of Benzyl, Amino, and Propargyl Alcohols to Aldehydes and Ketones under Mild Reaction Conditions

Arkivoc

Pyrrolo[1,2-a]quinazolines: synthesis and biological properties

Journal of the American Chemical Society

Redox-Neutral α-Oxygenation of Amines: Reaction Development and Elucidation of the Mechanism

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