Copper substituted hydroxyapatite (Ca10-xCux(PO4)(6)(OH)(2) (x=0.05-2.0), and fluorapatite Ca10-xCux(PO4)(6)(F)(2) (x=0.05-2.0) were synthesized by co-precipitation method. The synthesized compounds were characterized by powder X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, energy dispersive X-ray spectroscopy and thermo gravimetric analysis. The antimicrobial activity of the synthesized compounds were tested against the organisms Escherichia coli (Gram negative bacteria), Staphylococcus aureus (Gram positive bacteria) and Candida albicans (yeast) quantitatively by spread plate method. 100% reduction in the number of colonies were observed with Ca10-xCux(PO4)(6)(F)(2) (x=0.15-0.5) against E. colt. This material can be considered as good antibacterial agent for bone implantation.

Sumathi S

Department of Chemistry

School of Advanced Sciences

Vellore Campus

Buvaneswari G

Vellore Institute of Technology (VIT) is a private university located in&nbsp;Tamil Nadu, India. Founded in 1984, as Vellore Engineering College, the institution offers 20 undergraduate, 34 postgraduate, four integrated and four research programs. It has campuses in Vellore, Amravati, Bhopal and Chennai.

VIT is one of the top ranked private universities in India according to NIRF, THE and QS Rankings.&nbsp;Govt. of India has recognized&nbsp;VIT, Vellore as an&nbsp;Institution of Eminence. This has allowed VIT to take independent quality initiatives and move up in world ranking.

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VIT University

Ceramics International

In the present work, silk fiber (SF) and methylcellulose (MC) composites were fabricated by solvent casting method and characterized in detail. The interactions between SF/MC composites were studied in detail by Fourier transform infrared (FT-IR) spectroscopy and powder X-ray diffraction (XRD). The surface morphology and thermal stability were studied. Viscosity, thickness, folding endurance, tensile strength and antioxidant activity were analyzed for different ratios of SF/MC composite. Antimicrobial activity, in vitro biomimetic mineralization, hemocompatibility and cell viability of the SF/MC composite were studied. The deposition of calcium and phosphorus ions from simulated body fluid (SBF) onto SF/MC composite surface was evidenced from XRD, FT-IR and SEM–EDS. Inductively coupled plasma-optical emission spectrometry analysis (ICP-OES) was utilized to analyze leaching of Ca and P ions from the SBF. Hemolytic assay proves that the composites were compatible with blood and hemolytic ratio is found to be less than 5%. The MTT assay test against MG-63 suggests that the SF/MC composites are promising biomaterials for bone tissue engineering applications. © 2018, Springer-Verlag GmbH Germany, part of Springer Nature.

Polymer Bulletin

Preparation, characterization and in vitro biological study of silk fiber/methylcellulose composite for bone tissue engineering applications

Fulltext

Acta Biomaterialia

Cu-doping of calcium phosphate bioceramics: From mechanism to the control of cytotoxicity

Aliovalent ion substituted fluorapatite of formula Bi0.5Na0.5Ca4(PO4)3F was synthesized by co-precipitation method and characterized by powder X-ray diffraction, Fourier transform infrared spectroscopy, thermogravimetric analysis, scanning electron microscopy and energy dispersive X-ray spectroscopy. The catalytic activity of the synthesized compound was tested on one pot multicomponent reaction (Biginelli reaction) for the synthesis of 3,4-dihydropyrimidin-2(1H)-one and its derivatives. The compounds were confirmed by spectroscopic techniques and melting point. An enhanced yield was observed with this catalyst for the condensation of ethyl acetoacetate, urea and benzaldehyde compared to unsubstituted fluorapatite.

Reaction Kinetics, Mechanisms and Catalysis

Synthesis, characterization and catalytic activity of modified fluorapatite towards the multicomponent one-pot Biginelli condensation

Structure of hydroxyapatite (HAP) is more flexible towards ionic substitutions. Properties such as solubility, antimicrobial property can be tailored by substitutions. Substituted hydroxyapatite and fluorapatite of formulae BiNaCa3(PO4)3OH, Bi0.5M0.5Ca4(PO4)3OH (M=K, Ag), Ca10−xCux(PO4)6(OH/F)2 d(x=0.05–0.25) and Bi0.5Na0.5Ca4(PO4)3F were synthesized and characterized by powder XRD, FT-IR, SEM–EDAX and TGA. In vitro solubility of the synthesized compounds was studied in the phosphate buffered medium of pH 7.4 at 37&nbsp;°C. Based on the release of calcium and phosphorus ion concentration and pH, the solubility of these compounds is discussed. Bismuth and sodium co-substituted hydroxyapatite are found to be more soluble compared with other substituted apatite compounds and unsubstituted hydroxyapatite.

Journal of Crystal Growth

In vitro degradation of multisubstituted hydroxyapatite and fluorapatite in the physiological condition

Aliovalent ion substituted hydroxyapatite of formulae BiNaCa3(PO4)3OH, Bi0.5M0.5Ca4(PO4)3OH (M&nbsp;=&nbsp;K, Ag) were synthesized and characterized. Antimicrobial properties of these synthesized materials were studied quantitatively by spread plate method against the microorganisms Escherichia coli (gram negative bacteria), Staphylococcus aureus (gram positive bacteria) and Candida albicans (yeast). Among the substituted hydroxyapatite compounds bismuth and silver substituted compound of formula Bi0.5Ag0.5Ca4(PO4)3OH shown excellent activity against all the three organisms. Cytotoxicity study was carried out against mouse fibroblast NIH-3T3 cell line in two different concentrations 10&nbsp;μg/mL and 20&nbsp;μg/mL by MTT assay method.

Applied Surface Science

Antimicrobial and cytotoxicity evaluation of aliovalent substituted hydroxyapatite

Synthesis of fluorine substituted hydroxyapatite nanopowders and application of the central composite design for determination of its antimicrobial effects

Silver and fluoride doped hydroxyapatites: Investigation by microstructure, mechanical and antibacterial properties

Journal of Thermal Analysis and Calorimetry

A review on the thermal stability of calcium apatites

Materials Science and Engineering: C

In vitro biocompatibility and antimicrobial activity of wet chemically prepared Ca10−xAgx(PO4)6(OH)2 (0.0≤x≤0.5) hydroxyapatites

Copper substituted hydroxyapatite and fluorapatite: Synthesis, characterization and antimicrobial properties

Journal	Data powered by TypesetCeramics International
Publisher	Data powered by TypesetElsevier BV
ISSN	0272-8842
Open Access	0