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Corrigendum to “Synthesis of novel anticancer ruthenium–arene pyridinylmethylene scaffolds via three-component reaction” [Bioorg. Med. Chem. Lett. 26 (2016) 2695–2700]
Jadhav G.R, Jadhav, Gajanan Raosaheb, Sinha S, Chhabra M,
Published in Elsevier BV
2016
Volume: 26
   
Issue: 16
Pages: 4154 - 4155
Abstract
When this paper was first published there were a number of errors throughout the article. The corrected text is provided below: Paragraph 1 should read: ‘Target oriented molecule synthesis is an excellent approach in current drug discovery. Nowadays; a number of organic molecules have been developed as pharmacophore intended for a particular target. However, it was difficult to modify them in terms of biologically relevant chemical space since they are having very restricted structural diversity.1–3Therefore; investigation on the structurally unique potentially valuable unexplored chemical spaces is highly warranted. Currently, several transition–metal complexes have been expanded as potential drug candidates since they can eagerly accommodate higher coordination number and consequently access different molecular geometries which are not possible with pure organic scaffolds.’4Paragraph 3, sentence 17, should read: ‘In addition, Chow et. al. has discovered a series of novel ruthenium–arene Schiff base complexes via three component assembly which showed the low IC50values in inhibition of cell viability against a breast cancer cell line MCF7, a human ovarian cell line A2780 and A2780cisR.’25Paragraph 4, sentence 3, should read: ‘Herein, we have discovered a series of novel ruthenium–arene pyridinylmethylene scaffolds via three component assembly and evaluated there in vitro anticancer activity.’ Paragraph 5, should read: ‘Our intention was to synthesize a library of novel Ru–arene pyridinylmethylene complexes with ease of isolation, purification and operational simplicity via a one pot three-component approach. In that sense, we have modified the plate format synthesis25of Ru–arene Schiff base complexes. Initially, we have treated Pyridine-2-carboxaldehyde (1) with 2-aminopyridine (2a) in Methanol. But the formation of imine is irreversible as it hydrolyzed in aqueous medium. Thus, we prompted in multi-component approach for the synthesis of ruthenium–arene pyridinylmethylene complexes. The reaction involves three components, exclusively, Ru–arene dimer (3), Pyridine-2-carboxaldehyde (1), and 2-aminopyridine (2a).’ Paragraph 6, should read: ‘At the outset, dichloro p-cymene ruthenium(II) dimer (3) was stirred in methanol for 30 min to make the activated ruthenium monomer. Subsequently, 2 equiv of pyridine 2-carboxaldehyde (1) was added to attach the pyridine nitrogen with ruthenium. Finally 2 equiv of 2-aminopyridine (2a) was added to the reaction mixture and stirred for 24 h in ambient temperature. The progress of the reaction was monitored by TLC. NH2group of 2-amino pyridine initiates the imine formation and followed by complex with ruthenium progressively. A complete color change was observed after 24 h of reaction. Consequently, the solvent methanol was evaporated and crude product was recrystallized from 5% methanol in diethyl ether via vapor diffusion method. The general scheme & mechanistic pathway of the reaction was depicted below (Schemes 1 and 2.’ Paragraph 7: Delete the last sentence ‘The scheme of this general reaction was depicted below (Scheme 1).’ Reference 25 should read: 25. Chow, M. J.; Licona, C.; Wong, D. Y. Q.; Pastorin, G.; Gaiddon, G.; Ang, W. H. J. Med. Chem. 2014, 57, 6043. © 2016 Elsevier Ltd
About the journal
JournalData powered by TypesetBioorganic & Medicinal Chemistry Letters
PublisherData powered by TypesetElsevier BV
ISSN0960-894X
Open Access0