The corrosion inhibition of zinc coated steel sheets immersed in 3.5% NaCl with sulfisoxazole (SSZ) has been reported by weight loss, potentiodynamic polarization, electrochemical impedance spectroscopy, hydrogen permeation studies and quantum mechanical studies. All these techniques indicate that SSZ significantly inhibits zinc coated steel corrosion in a 3.5% NaCl medium. Polarization studies confirmed that the inhibition mode follows a mixed type. The adsorption of the compounds onto the zinc coated steel surface obeyed Langmuir adsorption isotherm. © 2019, Sociedade Portuguesa de Electroquimica. All rights reserved.