A series of spiro[indoline-3,3'-pyrrolizin]-2'-yl)-4-phenylquinoline-3-carboxylate 6 from 2-amino-5-chlorobenzhydrol 1, benzyl alcohols 3, and methyl or ethyl acetoacetate 2 is reported by the Cu(OAc)2, TEMPO catalyzed dehydrogenative Friedlander annulation/sp3–CH-functionalization/regioselective 1,3- dipolar cyclo- addition. Likewise, chimanine A analogues 7 were obtained using a similar strategy in DES (Deep Eutectic Solvents) as a reaction medium in excellent yields. © 2020 Wiley-VCH GmbH

Ethiraj K R

Department of Chemistry

School of Advanced Sciences

Vellore Campus

Nawaz Khan F

D. Pavithra

Vellore Institute of Technology (VIT) is a private university located in&nbsp;Tamil Nadu, India. Founded in 1984, as Vellore Engineering College, the institution offers 20 undergraduate, 34 postgraduate, four integrated and four research programs. It has campuses in Vellore, Amravati, Bhopal and Chennai.

VIT is one of the top ranked private universities in India according to NIRF, THE and QS Rankings.&nbsp;Govt. of India has recognized&nbsp;VIT, Vellore as an&nbsp;Institution of Eminence. This has allowed VIT to take independent quality initiatives and move up in world ranking.

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VIT University

European Journal of Organic Chemistry

Cu-TEMPO Catalyzed Dehydrogenative Friedlander Annulation/sp3 C–H Functionalization/Spiroannulation towards Spiro[indoline-3,3'-pyrrolizin]-2'-yl)-4-phenylquinoline-3-Carboxylates

Journal	Data powered by TypesetEuropean Journal of Organic Chemistry
Publisher	Data powered by TypesetWiley-VCH Verlag
ISSN	1434193X