Spatial data analysis is being used efficiently and the governments have realized that georeferenced data yields more insight with time and locations. Epidemiology is about the study of origin and distribution of diseases and dates back to the 1600s with the instance of cholera in London. Data Science has been evolving and when analyzed with Soft Computing techniques like Rough Set Theory (RST), Fuzzy Sets, Granulation Computing which encompasses the data in its original nature, results can be obtained with accrued accuracy. This survey paper highlights Spatial Data Mining methods used in the field of Epidemiology, identifies crucial challenges and discusses of the use of Soft Computing methods.