Ultrasound images play a major role in disease diagnosis and in medical treatments. These images are affected by speckle noise which occurs due to interference of the returning wave at the transducer aperture. This paper tries to denoise the ultrasound images by manually applying the speckle noise at various levels and apply the readily available filters to remove the speckle noise. Comparison of the results isanalyzed with various parameters like PSNR, UIQI, SSIM. On analyzing the results wiener filter seems to be effective in reducing the speckle noise. © 2016, International Journal of Pharmacy and Technology. All rights reserved.