This chapter discusses design and development of a surface Electromyogram (EMG) signal detection and conditioning system along with the issues of gratuitous spurious signals such as power line interference, artifacts, etc., which make signals plausible. In order to construe the recognition of hand gestures from EMG signals, Time Domain (TD) and well as Autoregressive (AR) coefficients features are extracted. The extracted features are diminished using the Principal Component Analysis (PCA) to alleviate the burden of the classifier. A four-channel continuous EMG signal conditioning system is developed and EMG signals are acquired from 10 able-bodied subjects to classify the 6 unique movements of hand and wrist. The reduced statistical TD and AR features are used to classify the signal patterns through k Nearest Neighbour (kNN) as well as Neural Network (NN) classifier. Further, EMG signals acquired from a transradial amputee using 8-channel systems for the 6 amenable motions are also classified. Statistical Analysis of Variance (ANOVA) results on classification performance of able-bodied subject divulge that the performance TD-PCA features are more significant than the AR-PCA features. Further, no significant difference in the performance of NN classifier and kNN classifier is construed with TD reduced features. Since the average classification error of kNN classifier with TD features is found to be less, kNN classifier is implemented in off-line using the TMS2407eZdsp digital signal controller to study the actuation of three low-power DC drives in the identification of intended motion with an able-bodied subject.