Pressure ulcers are the major problem in the stroke management and rehabilitation. Prevention of pressure ulcer is of keen interest and is achieved by frequently changing the position of patient on the mattress. However, the care needs to be intensive to address this issue; else it would lead to pressure ulcer or bed sores formation. Skin surface over the bony prominences provide comparatively more pressure than the other regions. Therefore they are called as pressure vulnerable regions. Skin over these regions is more susceptible for formation of ulcers. An engineering approach is needed to shift the accumulating pressure from the pressure vulnerable regions. Although pressure sensed in these region would be more than that of which sensed in other regions, shifting protocol has to be designed to channelize or to grade the pressure shift in order to avoid any injuries to the non pressure vulnerable region. This paper aims at devising one such protocol using MATLab and thereby designing the layout of mattress using Pro/Engineer: the number of partitions needed to cover the entire surface of the skin that is in contact with the mattress. © 2015 IEEE.