Sensitive Node Active Charge Cancellation technique (SNACC) is applied on the Complementary Folded Cascode amplifier (CFC) to study single event transients (SET) on this circuit. A Built-In-Detector (BID) is connected to the circuit to sense the variations of the currents in the op-amp and to represent their input and output characteristics. Two circuits are designed with and without SNACC, using UMC_CMOS_180nm process in cadence virtuoso environment. This work analyses to identify the effectiveness of Radiation Hardening By Design (RHBD) technique by comparing radiation sensitive and radiation hardened CFC amplifier. © 2019 Elsevier Ltd.