Header menu link for other important links
Design, synthesis and exploration of in silico α-amylase and α-glucosidase binding studies of pyrrolidine-appended quinoline-constrained compounds
Hemanth Kumar P, Jyothish Kumar L, Pavithrra G, , Karan R, ,
Published in Springer Science and Business Media LLC
Volume: 46
Issue: 3
Pages: 1869 - 1880
A series of new pyrrolidine-appended phenoxy-substituted quinoline derivatives were synthesized using 2-chloro-3-formyl quinoline. Initially, the second position of 2-chloro-3-formyl quinoline was successfully converted into various substituted phenoxy-substituted quinolines using various substituted phenols; then, its aldehyde function was reduced to its corresponding alcohols which is in turn converted into its corresponding pyrrolidine-appended phenoxy-substituted quinolines by treating it with 1-(2-chloroacetyl)pyrrolidine-2-carbonitrile. All these newly synthesized compounds were subjected to the in silico studies with the α-amylase and α-glucosidase enzymes to predict the binding affinity. © 2020, Springer Nature B.V.
About the journal
JournalData powered by TypesetResearch on Chemical Intermediates
PublisherData powered by TypesetSpringer Science and Business Media LLC
Open AccessNo