Detection of White Blood Cell (WBC) cancer diseases like Acute Myeloid Leukemia (AML), Acute Lymphoblastic Leukemia (ALL), and Myeloma is a complex task in medical field because they are sudden in onset. Our proposed method consists of designing and developing an automated system which will assist the medical professionals in correctly diagnosing all the types and sub-types of this disease. In this paper, we have proposed a novel method in which we have taken microscopic blood images as an input image. A dataset of 100 images in which 62 training and 38 testing images is taken. After that we have converted the image to proper format (YCbCr) for segmentation. For segmenting, we have used the combination of Gaussian Distribution, Otsu Adaptive Thresholding and for clustering we have used K-Means method. Using Gray Level Co-occurrence Matrix (GLCM), the features are extracted and were used for classification using Convolutional Neural Network (CNN). The overall accuracy of the system obtained after processing is 97.3%. © 2019 IEEE.