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DMFDMA catalyzed synthesis of 2-((Dimethylamino)methylene)-3,4-dihydro-9-arylacridin-1(2H)-ones and their derivatives: in-vitro antifungal, antibacterial and antioxidant evaluations
Jyothish Kumar L, ,
Published in Walter de Gruyter GmbH
Volume: 16
Issue: 1
Pages: 1077 - 1088

AbstractA series of 3,4-dihydro-9-arylacridin-1(2H)-ones was synthesized and enaminone function was introduced at the C-2 position using DMFDMA catalyst which in turn successfully converted into pyrazole, isoxazol, 1-phenyl-1H-pyrazole by treating it with reagents such as hydrazine, hydroxylamine and phenylhydrazine. These newly synthesized compounds were evaluated for their antibacterial activity against a series of Gram-Positive bacteria including Staphylococcus aureus, Bacillus cereus, Staphylococcus aureus MLS16 and Gram-Negative bacteria including Klebsiella planticol, Escherichia coli and Pseudomonas aeruginosa and also against fungal strains including Candida albicans, Candida parapsilosis, Candida glabrata, Candida aaseri, Aspergillus niger and Issatchenkia hanoiensis. The compounds 3a and 6a exhibited considerable antifungal activity (MIC value 0.007 and 0.006 μM) against Candida albicans and Aspergillus niger respectively. The compound 4a showed excellent antibacterial activity towards Escherichia Coli (MIC = 0.003 μM) and the compound 5a found to show prominent DPPH radical scavenging activity with EC50 value 16.85±1.5μg mL −1.

About the journal
JournalData powered by TypesetOpen Chemistry
PublisherData powered by TypesetWalter de Gruyter GmbH
Open AccessNo