A practical and metal free method for methylthiolation of imidazo[1,2-a]pyridines and other imidazo-fused heterocycles using DMSO-POCl3 complex is reported. The reactions are carried out at room temperature that give the corresponding methylthiolated products in good to excellent yield. Further, its application to indole has been demonstrated. © 2013 Published by Elsevier Ltd.

Mohana Roopan S

Department of Chemistry

School of Advanced Sciences

Vellore Campus

Patil S.M

Kulkarni S

Mascarenhas M

Sharma R

Roychowdhury A.

Vellore Institute of Technology (VIT) is a private university located in&nbsp;Tamil Nadu, India. Founded in 1984, as Vellore Engineering College, the institution offers 20 undergraduate, 34 postgraduate, four integrated and four research programs. It has campuses in Vellore, Amravati, Bhopal and Chennai.

VIT is one of the top ranked private universities in India according to NIRF, THE and QS Rankings.&nbsp;Govt. of India has recognized&nbsp;VIT, Vellore as an&nbsp;Institution of Eminence. This has allowed VIT to take independent quality initiatives and move up in world ranking.

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VIT University

Tetrahedron

This work describes the nitric acid catalysed synthesis of wollastonite (CaSiO3) nanoparticles (NP) from tetraethyl orthosilicate and calcium nitrate tetrahydrate. The formed calcium silicate nanoparticles were characterized by Fourier transform infrared spectroscopy (FTIR), Powder X-ray Diffraction (PXRD), and scanning electron microscopy (SEM) equipped with X-ray micro analysis. The CaSiO3 NPs showed an excellent yield (93%) towards the synthesis of quinolines via Friedlander reaction. The synthesized compound 3-dimethyl-7-nitro-9-phenyl-3,4-dihydroacridin-1(2H)-one was characterized by various spectroscopic techniques. © 2017 Taylor &amp; Francis Group, LLC.

Inorganic and Nano-Metal Chemistry

Synthesis of calcium silicate nanoparticles and its catalytic application in Friedlander reaction

A new and highly efficient microwave promoted N-alkylation of triazolo-quinazolinones was developed by treating various phenyl-substituted heterocyclic amines with benzyl chloride using K2CO3 as a base in the presence of DMF. Also the heterocyclic amines were synthesized by condensing the 3-amino-1,2,4-triazole substituted benzaldehydes and 1,3-cyclohexanedione in the presence of microwave irradiation under solvent free condition. The synthesized heterocycles 4a–o and 6a–o were further confirmed by using different spectroscopic techniques such as NMR and HRMS. The compounds 6a–o was studied for their solvatochromic property with increasing polarity of solvents. The determinations of 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) scavenging effect of the scaffolds 6a–o were carried out by UV–Vis spectrometer. In terms of IC50 all the compounds have shown remarkable antioxidant property compared with Ascorbic acid. © 2016 Elsevier B.V.

Journal of Molecular Liquids

Conventional spectroscopic identification of N-alkylated triazolo-quinazolinones and its antioxidant, solvatochromism studies

Dihydroquinazolinones is an important core structure reported with a wide variety of pharmacological activities. They are capable of undergoing various transformations because of its reactivity towards various reagents. The synthetic strategies for the functionalization and derivatization of the nucleus were explained. The diversified pharmacological actions of this moiety were illustrated through various biochemical pathways. The structural-activity relationship study of dihydroquinazolinones anticipated the relationship between the various substituents and its role in the pharmacological action. The main objective of this review is to summarize the importance of dihydroquinazolinones in the field of chemical biology.

Journal	Data powered by TypesetTetrahedron
Publisher	Data powered by TypesetElsevier BV
ISSN	0040-4020
Open Access	0