The transmission of a highly secured message that is highly essential in the global scenario today is possible by employing the DNA cryptography. Based on modified Shamir's secret algorithm as well as DNA based encryption and decryption, the present algorithm is arrived. In between server and clients, a provision of a three level secured message transmission is implemented. In this method, only when all the clients in the group are involved in the decryption process, decoding of the secret message is possible. This ensures security of first level. The server authenticates the clients to whom the secrets can be shared. It is the security of second level. The decoding of the original DNA sequence related to the secret is done only by the primers. That completes the final security level. The simulation validates that the proposed algorithm is much better from the point of security. © Medwell Journals, 2016.