Novel tridentate ONO hydrazone ligand (HL) and the corresponding vanadium(V) complex, [VO(HL)(Benz)], based on the ligand and benzhydroxamic acid, were synthesized and characterized using UV–visible, Fourier transform infrared, NMR and mass spectral studies. In order to assess the binding efficacy of the synthesized complex with DNA, UV absorption spectral titrations, fluorescence displacement assays using ethidium bromide and acridine orange dyes, circular dichroism, viscosity and molecular docking studies were carried out. Based on the results obtained, it is evident that the complex shows significant intercalating ability almost comparable to that of the standard intercalator drug cisplatin. The binding affinity values for the [VO(HL)(Benz)] complex and cisplatin were found to be (3.84 ± 0.08) × 104 M−1 and (4.27 ± 0.012) × 104 M−1. In addition, the cytotoxicity of [VO(HL)(Benz)] was also assessed by MTT assay against the MCF-7 cell line. Copyright © 2016 John Wiley &amp; Sons, Ltd.

Sheela A

Department of Chemistry

School of Advanced Sciences

Vellore Campus

Inamdar P

Vellore Institute of Technology (VIT) is a private university located in&nbsp;Tamil Nadu, India. Founded in 1984, as Vellore Engineering College, the institution offers 20 undergraduate, 34 postgraduate, four integrated and four research programs. It has campuses in Vellore, Amravati, Bhopal and Chennai.

VIT is one of the top ranked private universities in India according to NIRF, THE and QS Rankings.&nbsp;Govt. of India has recognized&nbsp;VIT, Vellore as an&nbsp;Institution of Eminence. This has allowed VIT to take independent quality initiatives and move up in world ranking.

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VIT University

Applied Organometallic Chemistry

Several polymetallic anionic clusters display a strong tendency to form robust ion-pairs with appropriate counter cations. We have isolated decavanadate cluster [H 2 V 10 O 28 ] 4– with, hitherto unreported, dimethylammonium ions, [N(CH 3 ) 2 H 2 ] 4+ as counter cations from vanadyl sulfate and N,N’-dimethylformamide (DMF). It is proposed, for the first time, that dimethylammonium ions are formed by reduction and simultaneous decarboxylation of DMF with oxidation of vanadyl sulfate occurring concomitantly under specified reaction conditions. The different colors observed during the course of the reaction are monitored by UV-Visible spectrophotometry. The structure of isolated cluster compound with four counter cations is confirmed by single crystal X-ray diffraction techniques. The compound is also tested for its DNA/BSA binding efficacy and cytotoxicity on human epitheloid cervix carcinoma (HeLa) cells along with vanadates—vanadium pentoxide and ammonium metavanadate. Based on the results, the cluster shows better IC 50 and binding values than vanadates. (Figure presented.). © 2018, © 2018 Informa UK Limited, trading as Taylor &amp; Francis Group.

Journal of Coordination Chemistry

Concomitant reduction of dimethylformamide and oxidation of vanadyl sulfate to N,N′-dimethylammonium decavanadate cluster and DNA, BSA binding, and cytotoxicity (HeLa) studies

The title family of mixed-ligand oxidovanadium(V) hydrazone complexes are [VVO(HL1)(hq)] (1) and [VVO(HL2)(hq)] (2), where (HL1)2− and (HL2)2− are the dinegative form of 2-hydroxybenzoylhydrazone of acetylacetone (H3L1) and benzoylacetone (H3L2), respectively, and hq− is the mononegative form of 8-hydroxyquinoline (Hhq). Complexes were used to determine their binding constant with CT DNA using various spectroscopic techniques namely, electronic absorption, fluorescence and circular dichroism spectroscopy. The binding constant values suggest the intercalative mode of binding with the CT DNA and follow the order: 2 &gt; 1. The bulky size as well as electron withdrawing property of the phenyl group (which is present in the β-diketone part of the hydrazone moiety in complex 2 in place of a CH3 group in complex 1) is responsible for the higher activity of 2 than 1. Complexes were screened for cytotoxic activity on cervical cancer cells and were found to be potentially active (IC50 value for 1 and 2 is 33 and 29 μM, respectively), even better than the widely used cis-platin (IC50 = 63.5 μM) and carboplatin (IC50 =  &gt; 200 μM) which is evident from the respective IC50 value. Nuclear staining experiment suggests that these complexes kill the SiHa cancer cells through apoptotic mode. The molecular docking study also suggested the intercalative mode of binding of these complexes with CT DNA and HPV 18 DNA. © 2017, © 2017 Informa UK Limited, trading as Taylor & Francis Group.

Journal of Biomolecular Structure and Dynamics

Structure-activity relationship on DNA binding and anticancer activities of a family of mixed-ligand oxidovanadium(V) hydrazone complexes

Inorganic Chemistry Communications

DNA interaction and cytotoxic activity of copper complex based on tridentate hydrazone derived ligand and nitrogen donor heterocycle

Journal of Photochemistry and Photobiology B: Biology

Protein binding and anticancer activity studies of ruthenium(II) polypyridyl complexes toward BEL-7402 cells

Journal of Inorganic Biochemistry

Synthesis, characterization, in vitro cytotoxicity and anticancer effects of ruthenium(II) complexes on BEL-7402 cells

Dalton Transactions

Synthesis, X-ray structure and in vitro cytotoxicity studies of Cu(i/ii) complexes of thiosemicarbazone: special emphasis on their interactions with DNA

Molecular BioSystems

Multi-spectroscopic and molecular modelling studies on the interaction of esculetin with calf thymus DNA

DNA binding behaviour of mixed ligand vanadium(V) complex based on novel tridentate hydrazone and benzhydroxamic acid ligand systems

Journal	Data powered by TypesetApplied Organometallic Chemistry
Publisher	Data powered by TypesetWiley
ISSN	0268-2605
Open Access	0