An efficient iodine-catalyzed approach to synthesise 1,3-thiazine has been developed, and this synthetic methodology is economical and uses cheap and readily available starting materials. This is the first example of constructing 1,3-thiazine via a sequential thia-Michael addition and cyclodehydration. © The Royal Society of Chemistry.

Sathishkumar K

Department of Electrical Engineering

School of Electrical Engineering

Vellore Campus

Sathiyanarayanan K

Department of Chemistry

School of Advanced Sciences

Vellore Institute of Technology (VIT) is a private university located in&nbsp;Tamil Nadu, India. Founded in 1984, as Vellore Engineering College, the institution offers 20 undergraduate, 34 postgraduate, four integrated and four research programs. It has campuses in Vellore, Amravati, Bhopal and Chennai.

VIT is one of the top ranked private universities in India according to NIRF, THE and QS Rankings.&nbsp;Govt. of India has recognized&nbsp;VIT, Vellore as an&nbsp;Institution of Eminence. This has allowed VIT to take independent quality initiatives and move up in world ranking.

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VIT University

RSC Advances

A new naphthalimide-based fluorescent probe [(S)-1 and (S)-2] employing (S)-BINOL unit as a chiral responsive group has been designed and synthesized. Ligand (S)-1 showed greater fluorescence enhancement towards (R)-amino alcohol and the value of enantiomeric fluorescence difference (ef) ratio reached as high as 7.07 for phenylalaninol while (S)-phenylalaninol did not show much enhancement in fluorescence, whereas ligand (S)-2 showed ef value of 4.49 for phenylalaninol. The fluorescence enhancement can be attributed to imine formation and H-bonding. Further, the R/S chiral selectivity of ligands (S)-1 and (S)-2 is opposite. The chiral discrimination ability of (S)-1 and (S)-2 was tested via fluorescence, NMR and CD spectral analysis. The results indicated that the sensor (S)-1 was very promising for use as a fluorescent sensor in determining the enantiomeric composition of α-amino alcohols. © 2018 Wiley-VCH Verlag GmbH &amp; Co. KGaA, Weinheim

ChemistrySelect

Naphthalimide-Based Chiral Fluorescence Sensor Employing (S)-BINOL Unit for Highly Enantioselective Recognition of α-Amino Alcohols with Opposite Chiral Selectivity

A simple and efficient three components domino reaction of γ-butyrolactam (2-pyrrolidinone), aromatic aldehyde and substituted thiophenol catalyzed by elemental iodine resulted in the formation of 1-((phenylthio)(phenyl)methyl)pyrrolidin-2-one derivatives. The stability of the synthesized analogues was evaluated in stimulated gastric fluid (SGF) and bovine serum albumin (BSA). In vitro anticancer activity was investigated in the low micromolar range and a few analogues were found to possess good activity. This current protocol provides several advantages like shorter reaction time, excellent yield and convenient work-up. © 2012 The Royal Society of Chemistry.

Organic & Biomolecular Chemistry

Efficient iodine catalyzed three components domino reaction for the synthesis of 1-((phenylthio)(phenyl)methyl)pyrrolidin-2-one derivatives possessing anticancer activities

Angewandte Chemie

Preise 2014 der Royal Society of Chemistry

Chemical Society Reviews

Higher-order multicomponent reactions: beyond four reactants

Tetrahedron Letters

Iodine-catalyzed three-component one-pot synthesis of naphthopyranopyrimidines under solvent-free conditions

MedChemComm

Recent applications of multicomponent reactions in medicinal chemistry

Domino condensation–heterocyclisation reactions: iodine catalyzed four component synthesis of 1,3-thiazine

Journal	Data powered by TypesetRSC Advances
Publisher	Data powered by TypesetRoyal Society of Chemistry (RSC)
ISSN	20462069
Open Access	0