One-pot and multicomponent reaction of ketones with malononitrile and pyrrolidine in ethanol affords 1,6-naphthyridines.

Asharani I-V

Department of Chemistry

School of Advanced Sciences

Vellore Campus

Lavanya M

Thirumalai D

Aravindan P.G.

Vellore Institute of Technology (VIT) is a private university located in&nbsp;Tamil Nadu, India. Founded in 1984, as Vellore Engineering College, the institution offers 20 undergraduate, 34 postgraduate, four integrated and four research programs. It has campuses in Vellore, Amravati, Bhopal and Chennai.

VIT is one of the top ranked private universities in India according to NIRF, THE and QS Rankings.&nbsp;Govt. of India has recognized&nbsp;VIT, Vellore as an&nbsp;Institution of Eminence. This has allowed VIT to take independent quality initiatives and move up in world ranking.

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VIT University

RSC Advances

A new series of functionalized fused pyridines 4(a–i) and fused pyrido[2,3-d]pyrimidines 8(a–c) were designed and synthesized through a multi-component reaction where in pyridine ring formation step plays a key role. All the newly formed compounds were well characterized by spectral techniques such as FTIR, 1 HNMR, 13 CNMR, HRMS and XRD. The potential therapeutic activities such as anti-inflammatory activity by protein denaturation and RBC membrane stabilization methods, and anti-oxidant activity by DPPH scavenging method of the newly synthesized compounds were studied. Interestingly, in-vitro testing of these compounds reveals that the compounds 4d, 4g, 4i, 8a and 8b showed comparable anti-inflammatory activity with respect to the standard drug, diclofenac. Similarly, fused pyridine 4f showed excellent anti-oxidant activity when compared with the standard, ascorbic acid. © 2018 John Wiley &amp; Sons A/S

Chemical Biology & Drug Design

One pot multi‐component synthesis of functionalized spiropyridine and pyrido[2,3‐d]pyrimidine scaffolds and their potent in‐vitro anti‐inflammatory and anti‐oxidant investigations

Various S-methylphenyl substituted acridine-1,8-dione series (4a–i) were synthesized through a one-pot cascade synthetic approach involving the reaction of 4-(methylthio)benzaldehyde and dimedone with a variety of amines as nitrogen source under reflux in ethanol. All the synthesized derivatives were characterized by using spectroscopic methods. In vitro evaluations of anti-inflammatory and antidiabetic efficacies of all the synthesized compounds were investigated. The anti-inflammatory results infer that the compounds 4c and 4d are showing excellent activity with an inhibition percentage of 80.58 ± 0.42, 81.72 ± 1.72 by membrane stabilization and 77.72 ± 0.76, 78.76 ± 0.81 by albumin denaturation methods, which is comparable with the standard diclofenac at a concentration of 100 μg/ml. Further, the antidiabetic assay revealed the moderate activity for the synthesized compounds at a concentration of 100 μg/ml with respect to their standard drug, acarbose. © 2017 John Wiley &amp; Sons A/S

One-pot cascade synthesis and in vitro evaluation of anti-inflammatory and antidiabetic activities of S-methylphenyl substituted acridine-1,8-diones

Biofabrication of CuNps from AmC aqueous leaf extract of various sizes with good anti-inflammatory and mosquito larvicidal efficacy.

RSC Adv.

One-step biofabrication of copper nanoparticles from Aegle marmelos correa aqueous leaf extract and evaluation of its anti-inflammatory and mosquito larvicidal efficacy

Tetrahedron Letters

Quinoxalinone–benzimidazole rearrangement: an efficient strategy for the synthesis of structurally diverse quinoline derivatives with benzimidazole moieties

Synthesis of fully-substituted pyridines and dihydropyridines in a highly chemoselective manner utilizing a multicomponent reaction (MCR) strategy

ChemInform

ChemInform Abstract: Microwave-Assisted Synthesis of Pyrimido[4,5-b][1,6]naphthyridin-4(3H)-ones with Potential Antitumor Activity.

ACS Combinatorial Science

Combinatorial Synthesis of Fused Tetracyclic Heterocycles Containing [1,6]Naphthyridine Derivatives under Catalyst Free Conditions

Domino synthesis of functionalized 1,6-naphthyridines and their in vitro anti-inflammatory and anti-oxidant efficacies

Journal	Data powered by TypesetRSC Advances
Publisher	Data powered by TypesetRoyal Society of Chemistry (RSC)
ISSN	20462069
Open Access	No