Palladium chemistry has grown into an extremely powerful strategy for C-C bond formation. The reported methodology is based on the eco-friendly synthesis of palladium nanoparticles (PdNPs) obtained from the methanolic extract of Carissa carandas (C. carandas) fruit extract. The synthesized PdNPs were characterized by UV-Vis spectroscopy, FTIR, SEM, TEM, XRD, zeta potential and particle size analyzer. The synthesized PdNPs were applied in Suzuki Miyaura Coupling reaction and further it was subjected to its toxicity assessment against the species of Artemia salina. The synthesis was carried out by both conventional and non-conventional methodology. The yield comparison was performed based on the amount of catalyst and condition. The catalytic efficiency and recyclability of the nanoparticles were performed. The post-synthesis comparative analysis on the quality of reaction based on E-factor and Eco-Scale to paramount its impact on the ecological friendliness.