Since Palladone ™ was withdrawn from market after being reported the adverse drug reactions caused by alcohol induced dose dumping of hyromorphone, there has been concern on the risk of alcohol induced dose dumping. In this study, the potent influence of alcohol on green tea polyphenols (GTP) loaded casein nanoparticles was studied and the mechanism of drug release was determined. GTP was encapsulated into casein nanoparticles and release of GTP was carried out in phosphate buffer saline (PBS) alone or with 10, 20, 30 and 40% alcohol. As the concentration of alcohol in the medium increased, there was an increase in the cumulative percentage of drug release. Up to 97% of GTP was released in 48 h when the medium contained 40% alcohol while it was only 73% in PBS. The release data for all batches showed good correlation with zero order kinetics and mechanism of release was observed to be anomalous mode of drug transport. Concentration of alcohol showed no effect on the drug release mechanism and no dose dumping was observed. Thus, GTP loaded casein nanoparticles are safe from the danger of alcohol induced dose dumping and would serve as a potent carrier for the delivery of GTP.