Shankhapushpi (Convolvulus pluricaulis) helps to prevent memory loss and it is a wonderful neurotonic. Previous studies support the fact that chronic stress in brain causes alterations in cognitive functions. The present study evaluated the effects of aqueous extract of Convolvulus pluricaulis on forced swimming cold stress induced rats. Spatial and locomotor activity was evaluated by Morris Water Maze to observe behavioral changes of rats. Stress increased escape latencies (acquisition) in Morris Water Maze test after 60 days induction. Posttreatment with AECP (100, 150 and 200 mg/kg/day) orally for 30 days, reduced the induced cognitive defects in the Morris Water Maze test. The serum antioxidant enzymes Glutathione peroxidase (GPx), Superoxide dismutase (SOD) and Glutathione (GSH) concentration were significantly decreased in cold stress induced groups when compared with controls. The AECP treated rats showed neuroprotective effects, ameliorates the cognitive disability and associated biochemical changes in brain in experimental cold water stress model. © 2018 Pharmascope Publications. All rights reserved.