Header menu link for other important links
X
Effect of pore forming agents on the physical characteristics and release kinetics of levofloxacin hemihydrate from floating alginate drug delivery system - An in vitro study
V. Krishnan, , F.P. Dass C,
Published in
2010
Volume: 24
   
Issue: 3
Pages: 139 - 145
Abstract
Floating Drug Delivery Systems (FDDS) provides a comprehensive solution for the retention of drug in stomach than the conventional dosage forms. In this study, floating alginate beads were prepared using sodium bicarbonate or potassium carbonate as a gas-forming agent and methyl cellulose as a binder. The effect of pore forming agents on the morphology, porosity, density and drug release kinetics of the beads were studied. Levofloxacin Hemihydrate was used as a model drug for in-vitro studies. The average pore size of the beads was measured using optical microscope which shows the pore size of the beads is in the range of 100ìm to 300ìm. The result indicates the better pore forming ability of sodium bicarbonate over potassium bicarbonate hence the potassium carbonate beads shows sustained release than the sodium bicarbonate beads.
About the journal
JournalTrends in Biomaterials and Artificial Organs
ISSN09711198