The purpose of the present work is to understand the evolution of residual stresses in weldments. The study made to weld the multipass dissimilar of Nickel-based superalloy Inconel 625 and stainless steel 316L using Continuous Current Gas Tungsten Arc Welding (CCGTAW) and Pulsed Current Gas Tungsten Arc Welding (PCGTAW) process employing ERNiCrMo-3 and ERNiCr-3 fillers. The L4 orthogonal array was used in the present experimentation process. Analysis of Variance (ANOVA) is applied for the optimization and to identify the critical parameters. In welding process, the size of the lattice size will be stressed due to welding parameters; the lattice dimension is measured by non-destructive technique X-Ray diffraction to investigate residual stress in the weldment in the lateral surface of the plate. X-Ray Radiography test has evaluated the quality of welds. The results show that root gap is a critical parameter and filler wire and weld processes are not critical. © 2018 Universidade Federal de Sao Carlos. All rights reserved.