The physicochemical properties, thereby the biological efficacy, of metal complexes are affected based on their structure and geometry that vary in the presence of coordinating and non-coordinating solvents. To investigate this, in the present work, we synthesized three hitherto unreported β-diketone-based oxovanadium(IV) complexes, namely [VO(tfdmh)2] (tfdmh =1,1,1-trifluro-5,5-dimethyl-2,4-hexanedione), [VO(dmh)2] (dmh = 2,2-dimethyl-3,5-hexanedione) and [VO(dbm)2] (dbm = 1,3-diphenylpropane-1,3-dione), and characterized them using electron paramagnetic resonance, UV–visible, Fourier transform infrared and electrospray ionization mass spectroscopies and single-crystal X-ray diffraction. The structural changes in the presence of dichloromethane, dimethylsulfoxide and dimethylformamide were analysed using spectroscopic techniques. Further, in vitro glucose uptake efficacy and cytotoxicity were assessed using C2C12 (rat skeletal muscle) and HeLa (human cervical cancer) cell lines, respectively. Copyright © 2017 John Wiley &amp; Sons, Ltd.

Sheela A

Department of Chemistry

School of Advanced Sciences

Vellore Campus

Chinthala C.P

Vellore Institute of Technology (VIT) is a private university located in&nbsp;Tamil Nadu, India. Founded in 1984, as Vellore Engineering College, the institution offers 20 undergraduate, 34 postgraduate, four integrated and four research programs. It has campuses in Vellore, Amravati, Bhopal and Chennai.

VIT is one of the top ranked private universities in India according to NIRF, THE and QS Rankings.&nbsp;Govt. of India has recognized&nbsp;VIT, Vellore as an&nbsp;Institution of Eminence. This has allowed VIT to take independent quality initiatives and move up in world ranking.

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VIT University

Applied Organometallic Chemistry

Several polymetallic anionic clusters display a strong tendency to form robust ion-pairs with appropriate counter cations. We have isolated decavanadate cluster [H 2 V 10 O 28 ] 4– with, hitherto unreported, dimethylammonium ions, [N(CH 3 ) 2 H 2 ] 4+ as counter cations from vanadyl sulfate and N,N’-dimethylformamide (DMF). It is proposed, for the first time, that dimethylammonium ions are formed by reduction and simultaneous decarboxylation of DMF with oxidation of vanadyl sulfate occurring concomitantly under specified reaction conditions. The different colors observed during the course of the reaction are monitored by UV-Visible spectrophotometry. The structure of isolated cluster compound with four counter cations is confirmed by single crystal X-ray diffraction techniques. The compound is also tested for its DNA/BSA binding efficacy and cytotoxicity on human epitheloid cervix carcinoma (HeLa) cells along with vanadates—vanadium pentoxide and ammonium metavanadate. Based on the results, the cluster shows better IC 50 and binding values than vanadates. (Figure presented.). © 2018, © 2018 Informa UK Limited, trading as Taylor &amp; Francis Group.

Journal of Coordination Chemistry

Concomitant reduction of dimethylformamide and oxidation of vanadyl sulfate to N,N′-dimethylammonium decavanadate cluster and DNA, BSA binding, and cytotoxicity (HeLa) studies

Here, we are reporting the glowing combustion synthesis of Na2CaSiO4 powders for the first time at low temperature. L-alanine was used as reductant, and nitrates of sodium and calcium were used as oxidants. Phase evolution and formation was studied using X-ray diffraction (XRD), Fourier transform infrared (FTIR), Thermo gravimetric analysis-Differential thermal analysis (TGA-DTA) techniques. Powder morphology and particle size distribution were characterized using scanning electron microscopy (SEM), dynamic light scattering (DLS) techniques. Results confirms the formation of single phasic, microcrystalline sodium calcium silicate (Na2CaSiO4 phase) in cubic crystal system. Evaluation of hemolysis and (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide) (MTT) tests suggest that Na2CaSiO4 powders exhibit negative response in in vitro conditions. Copyright © Taylor &amp; Francis Group, LLC.

Materials and Manufacturing Processes

Glowing Combustion Synthesis, Characterization, and Toxicity Studies of Na2CaSiO4Powders

Two diketone based oxovanadium complexes, viz., bis(4,4,4-trifluoro-1-phenylbutane-1,3-dionato)oxovanadium(IV) (1) and bis(1,1,1-trifluoropentane-2,4-dionato)oxovanadium(IV) (2), have been synthesized and characterized by spectroscopic and analytical techniques. The DNA binding and the cleaving ability of the complexes is assessed by UV-vis spectroscopy, fluorescence spectroscopy, viscometry and gel electrophoretic studies. The DNA binding constant values (Kb) are found to be 1.95±0.16×103M-1 for complex 1 and 1.064±0.17×103M-1 for complex 2, respectively. Based on the results of the spectral and viscosity studies, it is observed that the complexes, interestingly, have preferred minor groove binding with DNA. Further, the concentration-dependent oxidative cleavage pattern of pBR322 in the presence of the activating reagent, hydrogen peroxide, has also been discussed. In addition, the complexes have shown moderate cytotoxic activity by inducing apoptosis against the cervical cancer cell line, HeLa. The results of in silico analysis and logP predictions are found to be in good agreement with the experimental observations. Thus, synthesized oxovanadium complexes have displayed promising DNA binding behavior and DNA cleavage activity with moderately cytotoxic nature. © 2015 Elsevier B.V.

International Journal of Biological Macromolecules

Exploration of DNA binding mode, chemical nuclease, cytotoxic and apoptotic potentials of diketone based oxovanadium(IV) complexes

Diabetes mellitus is one of the metabolic disorders resulting from excess production of reactive oxygen species (ROS) over the normal level and also due to dysfunction in the antioxidant defense mechanism, possibly both occurring simultaneously. Excess ROS are normally scavenged by antioxidants. Transition metal complexes exhibit such antioxidant property by scavenging the excess free radicals (one type of ROS) in such disorders. In this study, we report on synthesis, characterization, and in vitro study on antioxidant property of a few new ester-based vanadium(IV) complexes, namely, bis(1,1- dimethylethylpropanedioato)oxovanadium(IV) - [VO(DTBM)2]; bis(methyl-3-oxopentanoato)oxovanadium(IV) - [VO(MPA)2]; bis(ethyl-3-oxopentanoato)oxovanadium(IV) - [VO(EPA)2]; bis(2-methyl-1,3-dimethylpropanedioato)oxovanadium(IV) - [VO(DMMM)2] and bis(2-bromo-1,3-diethylpropanedioato)oxovanadium(IV) - [VO(BDEM) 2], and also furan-based vanadium complexes. Antidiabetic potential of selected complexes has been estimated. An attempt has also been made to correlate antioxidant and antidiabetic potentials of selected complexes. Our study reveals that compounds exhibiting higher glucose lowering effect seem to possess good antioxidant potential as well. © 2012 Springer Science+Business Media New York.

Medicinal Chemistry Research

A possible correlation between antioxidant and antidiabetic potentials of oxovanadium(IV) complexes

The ester-based vanadium complexes, bis(methylacetoacetato) oxovanadium (IV), bis(ethylacetoacetato) oxovanadium(IV) and bis(ethylbenzoylacetato) oxovanadium(IV), have been prepared and characterized by physicochemical and spectroscopic methods. The biological efficacies of the complexes were investigated. These complexes possess substantial glucose lowering ability and also show improved glucose tolerance effect. © 2010 Springer Science+Business Media B.V.

Transition Metal Chemistry

A study on the glucose lowering effects of ester-based oxovanadium complexes

Since 1985, when Heyliger et al. first reported the in vivo insulin mimetic activity of oral vanadate, extensive studies exploring vanadium chemistry, including the synthesis of novel complexes and their biological effects both in vitro and in vivo have been pursued. Such complexes have emerged as possible potential agents for diabetes therapy. Among the several existing compounds, diketone based vanadium complexes have been chosen for the current study. Two new complexes namely bisdimethylmalonatooxovanadium(IV) and bisdiethylmalonatooxovanadium(IV) have been synthesized and characterized by UV-visible, FTIR and mass spectral studies. The antidiabetic activity of the complexes was proved by animal study. The results show that the above complexes have comparable antidiabetic potential with respect to the standard drug as well as with bisacetylacetonatooxovanadium(IV) which has been studied earlier by Reul et al. © 2008 Elsevier Masson SAS. All rights reserved.

European Journal of Medicinal Chemistry

New diketone based vanadium complexes as insulin mimetics

Effect of solvent coordination on the structure of β-diketone-based vanadyl complexes and assessment of in vitro antidiabetic activity and cytotoxicity

Journal	Data powered by TypesetApplied Organometallic Chemistry
Publisher	Data powered by TypesetWiley
ISSN	0268-2605
Open Access	0