A novel, flexible and strong technique for the synthesis of indazolo[3,2-b]quinazoline motifs using NiTiO3 as a mild catalyst was reported. The reaction was effectively created utilizing 3,4-dihydronaphthalen-1(2H)-one (1a), benzaldehyde (2a) and 1H-indazol-3-amine (3a) by visible light/ultrasonic medium. Moreover, a proposed reaction pathway included Claisen–Schmidt condensation; Michael reaction with the nucleophilic endocyclic processes and oxidation for three-component domino convention is also examined. The synthesized compounds were fluorescent in nature and have high fluorescence quantum yields. © 2020 John Wiley & Sons Ltd