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Effective water mediated green synthesis of polysubstituted quinolines without energy expenditure
Gopi P,
Published in Springer Science and Business Media LLC
Volume: 148
Issue: 6
Pages: 1043 - 1049
Abstract: This study explores a green methodology for the synthesis of polysubstituted quinolines through Friedländer annulation using water as a solvent. To evaluate the viability of this methodology, results obtained were compared with methods involving the usage of energy, such as mechanical stirring, heating, microwave irradiation, and solvent free heating reaction. To demonstrate the efficiency and consistency of this method, a bulk batch reaction has been performed using this protocol and many quinoline derivatives have been synthesised and characterised by 1H, 13C NMR, melting range, and HR-MS. Graphical abstract: [Figure not available: see fulltext.]. © 2016, Springer-Verlag Wien.
About the journal
JournalData powered by TypesetMonatshefte für Chemie - Chemical Monthly
PublisherData powered by TypesetSpringer Science and Business Media LLC
Open AccessNo