An analysis has been carried out the effect of binary chemical reaction on the MHD Casson fluid flow over an exponentially stretching surface in the presence of Cattaneo-Christov heat flux. Additionally, the aspects of binary chemical reaction effects with modified Arrhenius activation energy are analyzed. The stretching velocity, reaction rate, wall temperature and wall concentration are expected to differ according to specific exponential form. Appropriate self-transformed variables are used to deal with non-linear differential systems which are solved by the Runge-Kutta scheme. The impacts of active parameters are manifested graphically in velocity, temperature and concentration fields for two different fluid cases namely Newtonian and Non-Newtonian. This investigation divulges that the Newtonian fluid has a higher temperature than non-Newtonian fluid. Strengthen the magnetic field causes the Newtonian/non-Newtonian fluid flow tends to declines. © IMechE 2020.