Morindacitrifolia, also known as noni belongs to the family Rubiaceae has been in high demand in yurvedic medicine. It has been used long since in various cultures as a medicine for cure of various ailments. This review attempts to analyze the evidence for the claim as a therapeutic cure for many diseases. This review article is presented to compile all the updated information on its phytochemical and pharmacological activities. Studies indicate fruit juice possesses antioxidant, anti-inflammatory, apoptotic and anticancer, properties. Various effects like antibacterial, anti-fungal, anti HIV, antiboneresorption, antispasmodic, antipyretic, anti-diarrheal, anti-allergic, immunomodulation, cardiotonic, hypo-lipidemic, anti-microbial, gastro-protective have been studied. Clinical trials using this fruit juice for a variety of conditions should also be conducted. Currently the market is flooded with products with claim cure for all ailments. This review analyzes the beneficial effects of the use of Morinda Citrofolia. Evidence based result shows that consumption of noni could be beneficial both protective and curative.