Gastrointestinal disorders are very common among adults; the contaminated food and water are the main sources of the organisms which can cause gastric problems. Due to the intake of antibiotic drug against the pathogen causing gastrointestinal disorders, the bacterial strains are becoming resistant to the particular. To overcome this, citrus fruit peel extract can be used to treat these disorders. The citrus fruit peel extract used Citrus paradisi Mac fad (Grapefruit) Citrus sinensis (Orange), Citrus Limon (Lemon), and Citrus aurantifolia (Lime) against the gastrointestinal pathogens and lesser side effects than the synthetic drugs used against gastrointestinal pathogens.