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Enantioselective fluorescent sensing of chiral carboxylic acid by engaging boronic acid and BINOL
Munusamy S.K, , Muralidharan V.P, Balijapalli U,
Published in Elsevier BV
Volume: 244
Pages: 175 - 181
Two BINOL based boronate esters, namely (S)-2 and (S)-3, were designed and synthesized. Fluorescent recognition studies of (S)-2 towards enantiomers of mandelic acid revealed that sensor (S)-2 exhibited high fluorescent enantioselective response towards mandelic acid. The other boronate ester (S)-3 which did not have hydroxyl group in the minor groove of BINOL did not show any fluorescent chiral discrimination. Their enantioselective recognition was also studied by means of1H NMR spectroscopy. The results indicated that the sensor (S)-2 was very promising as a chiral fluorescent sensor for the recognition of chiral carboxylic acid in THF solvent. Theoretically predicted hydrogen bonding interactions revealed a favorable chiral recognition between the receptor and L-mandelic acid, which is well correlated with experimentally observed enantioselective recognition phenomenon. © 2016 Elsevier B.V.
About the journal
JournalData powered by TypesetSensors and Actuators B: Chemical
PublisherData powered by TypesetElsevier BV
Open Access0