Cloud computing has gained precise attention from the research community and management of IT, due to its scalable and dynamic capabilities. It is evolving as a vibrant technology to modernize and restructure healthcare organization to provide best services to the consumers. The rising demand for healthcare services and applications in cloud computing leads to the imbalance in resource usage and drastically increases the power consumption resulting in high operating cost. To achieve fast execution time and optimum utilization of the virtual machines, we propose a multi-objective hybrid fruitfly optimization technique based on simulated annealing to improve the convergence rate and optimization accuracy. The proposed approach is used to achieve the optimal resource utilization and reduces the energy consumption and cost in cloud computing environment. The result attained in our proposed technique provides an improved solution. The experimental results show that the proposed algorithm efficiently outperforms compared to the existing load balancing algorithms. © 2017