Background: Many analog design techniques and methodology have been devised for better performance of amplifier. Nowadays operational amplifier is the backbone of the analog and mixed-signal device. It is fundamental block of the many design circuit that utilizes high gain, high bandwidth, fast settling time. Op-amp is one of the basic building blocks of analog circuit which has wide range of application such as biomedical application, ADC converter, switched capacitor filter. Methods/Statistical analysis: This paper presents the novel structure of folded cascode amplifier for enhancing the gain. In this quadruple recycling folded cascode (QRFC), operational transconductance (OTA) amplifier is used to improve the performance over the conventional folded cascode (FC), double recycle, and improved recycle folded structures. The proposed structure uses positive feedback, cross-coupled transistors which significantly improve its unity gain bandwidth, DC gain, and slew rate as compared to others OTA structures. Circuit-level simulations and analysis results were done with 180 nm CMOS technology validate the improved gain of 95 dB for single-stage fully differential mode and enhance bandwidth of 185.2 MHz. Findings: A location-based layout study is done. The problem with this method is that while we go to increase gain of amplifier as much as high we have to compromise with phase margin. Application/Improvements: By using this current reuse technique we achieve high gain as compared with the other operational amplifiers. Also due to this method, its gain bandwidth frequency also increases. © 2018, Springer Nature Singapore Pte Ltd.