Among the azole antifungal agents, fluconazole acts best on many fungal pathogens like Blastmoyces dermatitidis, Microsporum, Cryptococcus neoformans and Candida albicans. Fluconazole is fungistatic rather than being fungicidal and hence causes resistance of certain fungi. This drug is found to be poorly aqueous insoluble but possess good bioavailability. Hence, we tried to improve on the solubility using a new lipophilic environment as the drug is highly lipophilic. Our novel microemulsion drug delivery system for fluconazole was formulated using cinnamon oil, tween 20 and water (6:30:64 v/v) without any high-energy methods. The optimized formulation was checked for various parameters to demonstrate the internal state of the system. Cinnamon oil based drug-incorporated system (F5) showed higher solubility, hydrodynamic diameter of 10-45 nm and good stability. Also, the surfactant concentration was found to have a direct relation to stability and viscosity. Moreover, the system due to the presence of cinnamon oil may have additional influence on the efficacy against certain pathogens. Thus, our novel formulation has added advantage in serving as best drug delivery agent for fluconazole.