The intention of this article is to explore the entropy generation in EMHD hybrid nanofluid on a stagnation point in the presence of slips, heat generation and viscous dissipation. The fluid in the enclosure is water containing hybrid nanoparticles Ag-Cu. Suitable self-similarity variables are employed to transform the nonlinear differential systems into an ordinary differential system, which computed via homotopy perturbation method (HPM). The comparison with the homotopy perturbation method (HPM) gives an accurate and reliable result than the numerical method (Runge-Kutta method). The graphical results are expressed for velocity, temperature, entropy generation, Bejan number, skin friction and Nusselt number with an impact of active parameters. The higher values of electric field enhancing the velocity whereas the opposite nature for a magnetic field parameter. The entropy generation rises for higher values of a magnetic parameter, Eckert number and temperature difference parameter. In the magnetic field and electromagnetic field plays an important role in biomedical applications especially radiofRequency ablation (RFA), magnetic resonance imaging (MRI), cancer therapy, tumor therapy, malaria infection. This theoretical investigation may be profitable in biomedical engineering, especially cardiology, cure of skin disorders and treat tumors in Uterus. © 2020 IOP Publishing Ltd Printed in the UK